… system during pregnancy, as well as its anti-fibrotic and anti-… effective than the ACE inhibitor
enalapril in reducing cardiac … experimental design in pre-clinical studies versus clinical trial …

… Heart Association acute heart failure activin receptor-like kinase analysis of variance activator
protein 1 angiotensin-receptor-neprilysin-inhibitor angiotensin 2 adenosine triphosphate …

… Serelaxin mediates signal transduction in fibroblasts through its cognate receptor RXFP1
and … The antifibrotic efficacy of serelaxin is experimentally equivalent if not better than current …

… -term outcome benefits in acute heart failure. Clinical observations … Despite differences in
experimental design and study subject… of the putative anti-fibrotic effects of serelaxin, including …

… In the same experimental model, serelaxin treatment reduced … anti-fibrotic and anti-hypertrophic
actions of serelaxin have … of enalapril and serelaxin diminished cardiac fibrosis two-fold …

… need to develop novel and effective anti-fibrotic therapies in cardiovascular disease. In this
… relaxin more effectively ameliorated cardiac fibrosis than enalapril in an experimental model …

… Serelaxin is safe and efficacious in protecting organs and … serelaxin alleviates heart failure
by inhibiting cardiac fibrosis … enzyme inhibitor enalapril decreases cardiac fibrosis greatly [24]. …

… in the majority of cardiovascular diseases and is a key … to reduce organ fibrosis in various
experimental models. (47,48) … such as ARBs and ACE inhibitors that may provide additional …

… is effective in reversing a broader range of diabetes-induced … The anti-fibrotic effects of
serelaxin have been well documented in a wide variety of experimental models of heart failure 49 …

… relaxin, serelaxin (RLX), mediates its anti-fibrotic actions by … that RLX is more efficacious
than MCC950 in suppressing … its antifibrotic actions in the setting of cardiovascular disease. …